College football picks, schedule: Predictions against the spread, odds for top

Following the chaos last week that effectively turned the 2022 college football season on its head, top-25 teams who are big favorites in Week 3 will perhaps be a little more cautious Saturday. With two games between ranked opponents on the schedule and a number of top-tier nonconference games to be played, plenty can still shake out before league play begins in earnest to close the month of September.

Most notable Saturday is the nightcap as No. 13 Miami visits No. 24 Texas A&M with the Aggies fresh off one of those aforementioned upset losses to Appalachian State. The Hurricanes are looking to flex under first-year coach Mario Cristobal, while Aggies coach Jimbo Fisher is aiming to keep his seat from becoming too hot. Speaking of Cristobal, his former team is featured in that other top 25 showdown as No. 25 Oregon hosts No. 12 BYU. The Cougars are feeling themselves after a huge home win over Baylor, while the Ducks are still aiming to bounce back from a rough showing against Georgia in Week 1. 

Also on the slate are No. 6 Oklahoma welcoming rival Nebraska fresh off the Cornhuskers’ firing of coach Scott Frost, newly minted No. 1 Georgia visiting SEC East rival South Carolina and Auburn welcoming a tough nonconference test from No. 22 Penn State in the featured game on CBS. In other words, there will be no shortage of storylines to chew on before Saturday is out.

Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff onward. Let’s take a look at our expert picks for the best games in Week 3.

Odds via Caesars Sportsbook | All times Eastern

No. 6 Oklahoma at Nebraska

Noon | Fox, fuboTV (Try for free) — Oklahoma has not faced a Power Five foe under new coach Brent Venables. In fact, its two wins were against teams ranked No. 95 and No. 108 in the CBS Sports 131 Rankings. While Nebraska is struggling, the talent jump — along with a new coaching direction — makes this game slightly trickier than early results would assume. A worse Nebraska team played a better Oklahoma team within seven points last season. With the game being held in Lincoln, Nebraska, don’t expect things to get out of hand. Pick: Nebraska (+11.5) — Shehan Jeyarajah

Follow Oklahoma at Nebraska live on CBS Sports.

No. 1 Georgia at South Carolina

Featured Game | South Carolina Gamecocks vs. Georgia Bulldogs

Noon | ESPN, fuboTV (Try for free) — South Carolina’s woes on the offensive line spell disaster in this matchup. The Gamecocks are struggling to protect quarterback Spencer Rattler and haven’t shown much of a rushing attack through two games. Georgia’s defense looks like it has hardly dropped off at all after having five…

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